World takes stock of COVID-19 drug remdesivir after US snaps up supplies

first_imgSome governments in Europe and Asia said on Wednesday they have enough of Gilead’s COVID-19 anti-viral remdesivir for now despite fears of shortages since the US drugmaker pledged most output to its home market for the next three months.The pharmaceutical company’s move stirred the global debate about equitable access to drugs and brought concerns about accessibility, especially in regions where coronavirus rates are still high or there have been new outbreaks.Remdesivir is in high demand after the intravenously-administered medicine helped shorten hospital recovery times in a clinical trial. It is believed to be most effective in treating COVID-19 patients earlier in the course of disease than other therapies like the steroid dexamethasone. Still, because remdesivir is given intravenously over at least a five-day period it is generally being used on patients sick enough to require hospitalization.Britain and Germany said they had sufficient reserves for now, though they were weighing options for when those might be exhausted.South Korea, for its part, has started distributing stocks, but plans talks to purchase more supplies in August.The US Department of Health and Human Services (HHS) this week said it had secured all of Gilead’s projected production for July and 90% of its production in August and September, in addition to an allocation for clinical trials. The European Union (EU) said on Wednesday it was in negotiations to obtain doses for its 27 member nations.”Supply chains under strain””The buying-up of remdesivir is disappointing news, not necessarily because of the shortages it implies for other countries, but because it so clearly signals an unwillingness to cooperate with other countries, and the chilling effect this has on international agreements about intellectual property rights,” said Ohid Yaqub, senior lecturer at the Science Policy Research Unit of Britain’s University of Sussex.Jonathan Van-Tam, deputy chief medical officer and lead for Britain’s Department for Health and Social Care, told a parliamentary hearing on Wednesday that new drugs such as remdesivir were likely to be in “relatively short supply in the first instance” versus existing generic ones like dexamethasone.The German health ministry said that the conditional market approval Gilead is expected to receive from the EU’s executive Commission this week carries an implied obligation to deliver sufficient quantities in the future.”We trust Gilead will meet this obligation,” it said.Gilead has said it linked up with generic drugmakers based in India and Pakistan to supply remdesivir in 127 developing countries, but it has not discussed in detail its supply strategy for developed nations outside the United States.”The issue is the high demand for a drug that is still an investigational medicine and probably had not been scaled up to a manufacturing level when the outbreak occurred,” said Gino Martini, the UK Royal Pharmaceutical Society’s chief scientist.”The US action means clinical supply chains will be under strain. It will be down to manufacturers Gilead to boost production in order to satisfy demand for the use of remdesivir.”Topics :last_img read more

Everything You Need to Know as School Starts Tomorrow in PBC

first_imgMeanwhile, the 1st District Court of Appeal in Tallahassee has made a decision on the issue over whether the state has the right to force schools to reopen.On July 6, Florida Education Commissioner Richard Corcoran issued an emergency order that required public schools statewide to reopen their campuses on weekdays or risk the possibility of losing state funding. With the school year set to begin with virtual-only learning in Palm Beach County on Aug. 31, parents, students and staff are making last-minute preparations.“This will not be a typical year,” said Dr. Donald Fennoy, the Superintendent of the School District of Palm Beach County, said during a news conference last week.The district made the decision in July to delay reopening until the end of August, and to offer remote instruction exclusively for the time being.Schools are slated to reopen their campuses one week after the county moves to phase 2 of Gov. Ron DeSantis’ reopening plan. However, parents and students would still have to option to continue with virtual learning at that point, if they so choose.For now, students will follow a regular bell schedule, and teachers will offer live classes every weekday, just as they would on campus.“Please know, the school board and I are committed to reopening our campuses as soon as it is safe to do so,” Fennoy added.A recent district survey revealed that nearly 20 percent of students will choose to continue learning online when phase 2 begins, while 37 percent will return to campus. Another 39 percent remain unsure.District officials emphasize that parents and students may not move between online and campus learning from one week to the next.Last week, the district sent all families an email with a guide to the school year, available here.In addition, the district has established a hotline at (561) 969-5840 to answer questions about the start of the 2020-21 school year.The school district’s IT Service Desk is available at (561) 242-4100 Monday through Friday from 6:30 a.m. to 5 p.m.The first day of school on Monday will be very different than any school year before. But one thing hasn’t changed. We are here for you and we are in this together. #GoingTheDistancePBCSD @AngelaBrentHar1 @ShineonSPES pic.twitter.com/OEZW1uu0Hg— PBCSD (@pbcsd) August 30, 2020 Last Friday, the 1st District Court of Appeal sided with Corcoran and Gov. Ron DeSantis, by issuing a stay Lee County Circuit Court Judge Charles Dodson’s ruling that the state mandate was unconstitutional.Nonetheless, the case will not necessarily go straight to Florida’s Supreme Court, as the appeals court struck down that request from both sides in the case.Final briefs in the case are due by Sept. 9, according to the News Service of Florida and Miami television station WFOR.The Florida Education Association (FEA) originally brought the issue to Dodson, arguing that the state’s mandate violated the Florida Constitution’s guarantee of “safe” and “secure” public schools.Now, FEA President Fedrick Ingram is fighting back.In a statement released after Friday’s ruling, he says, “We are going to keep fighting because lives are at stake. This is not about closing schools or opening schools. This is about allowing local districts to do what is best to protect local families.”Last week, Dodson had issued a temporary injunction leaving decisions up to local school districts.Allowing Dodson’s order to stay in effect “would threaten to interfere with the ongoing reopening of schools by local districts and disrupt plans that families have made with respect to their children’s education,” the state’s lawyers have argued.Nearly 60 percent of the 2.8 million public school students in Florida have registered for in-person classes, state education officials say.850 WFTL wishes everyone success and safety during the new school year.last_img read more

Mayweather unfazed by ‘dirty’ McGregor

first_imgDon’t miss out on the latest news and information. Vilma Santos, Luis Manzano warn public of fake account posing as her Teen gunned down in Masbate Albay to send off disaster response team to Batangas Marcosian mode: Duterte threatens to arrest water execs ‘one night’ LATEST STORIES Floyd Mayweather Jr. and Conor McGregor. AFP/GETTY IMAGES FILE PHOTOLOS ANGELES—Floyd Mayweather has accused Conor McGregor of “fighting dirty” in training but is confident of a clean battle when the two men meet in their August 26 superfight.Mayweather told reporters on a conference call on Thursday he believed mixed martial arts star McGregor had used illegal tactics in sparring sessions.ADVERTISEMENT “A lot of rabbit punching, a lot of illegal shots, behind the head,” he added.READ: McGregor vows fast finish against MayweatherMcGregor has hired veteran referee Joe Cortez during his training camp to help advise on boxing rules and ensure he fights clean.“He’s had Joe Cortez in his training camp and I’ve still seen him being extremely dirty,” Mayweather said.Veteran referee Robert Byrd will be responsible for managing the fight and Mayweather is confident he will maintain control of the contest. Byrd officiated in Mayweather’s 2013 win over Robert Guerrero in Las Vegas.ADVERTISEMENT “I truly believe the referee is going to do a great job,” Mayweather said.“The referee’s job is to keep the fight clean. He don’t have anything to worry about. I’m looking forward to following the Queensberry rules of boxing,” he added.Mayweather retired from boxing in 2015 with a perfect 49-0 record to emulate former heavyweight legend Rocky Marciano. A win against McGregor would see the welterweight become the only man to ever hold a perfect 50-0 record.Mayweather insisted however that moving clear of Marciano’s historic benchmark was not on his mind.“Even though this is my 50th fight, this is not my focus,” Mayweather said. “Rocky Marciano is a legend, he did it his way. I just like to do it the Mayweather way.”Win or lose, Mayweather is adamant that nothing will be able to tempt him back into the ring following his return against McGregor. He reiterated an earlier statement that this month’s fight will be his last.BACKSTORY: Mayweather ‘out of retirement for McGregor’“This is my last one. I gave my word to (adviser) Al Haymon, I gave my word to my children, I don’t want to break that,” Mayweather said.“I’m going to stick to my word — this is going to be my last fight.” Korea ousts Gilas Pilipinas End of his agony? SC rules in favor of Espinosa, orders promoter heirs to pay boxing legendcenter_img MOST READ 787 earthquakes recorded in 24 hours due to restive Taal Volcano Sports Related Videospowered by AdSparcRead Next Filipinos turn Taal Volcano ash, plastic trash into bricks PLAY LIST 01:40Filipinos turn Taal Volcano ash, plastic trash into bricks01:32Taal Volcano watch: Island fissures steaming, lake water receding02:14Carpio hits red carpet treatment for China Coast Guard02:56NCRPO pledges to donate P3.5 million to victims of Taal eruption00:56Heavy rain brings some relief in Australia02:37Calm moments allow Taal folks some respite 2 nabbed in Bicol drug stings The undefeated former welterweight king, who is coming out of retirement to fight McGregor in Las Vegas, said he had spotted rabbit punches in footage of McGregor’s sparring session with Paulie Malignaggi.McGregor, who has never fought in a professional boxing contest, appears to floor Malignaggi in the footage.FEATURED STORIESSPORTSEnd of his agony? SC rules in favor of Espinosa, orders promoter heirs to pay boxing legendSPORTSRedemption is sweet for Ginebra, Scottie ThompsonSPORTSMayweather beats Pacquiao, Canelo for ‘Fighter of the Decade’Mayweather, 40, was unimpressed.“I had a chance to see it and my thought were, it was interesting,” Mayweather said of McGregor’s Malignaggi knockdown. Ai-Ai delas Alas on Jiro Manio: ‘Sana pinahalagahan niya ang naitulong ko’ 787 earthquakes recorded in 24 hours due to restive Taal Volcano View commentslast_img read more

Booth: Groves will relish his Arena return

first_imgGeorge Groves’ trainer and manager Adam Booth says the Hammersmith man will relish the chance to fight on another major show at the O2 Arena on 25 May.Unbeaten Commonwealth champion Groves, 25, will face Noe Gonzalez Alcoba of Uruguay at the same venue he beat arch-rival and fellow West Londoner James DeGale at in 2011.The fight will be chief support to the world title clash between Mikkel Kessler and Nottingham’s IBF champion Carl Froch, who has been mooted as a possible future opponent for Groves.“George loves it – he absolutely loves fighting on big shows,” Booth told West London Sport “He has had his fair share of experience fighting on big shows behind David Haye, as well as the DeGale one, so he is looking forward to it.”Last year Groves was forced to withdraw from two fights – including a world title challenge against the then WBO champion Robert Stieglitz – because of injury.But a victory next month would maintain his unbeaten record as his hopes of securing a world title fight later this year.Booth said: “We have got four weeks of training left. He has started sparring and everything is, touch wood, alright at the moment. I’m superstitious so I don’t want to curse it.”He added: “If Carl beats Kessler, I think he [Froch] will have his eyes set on people like Andre Ward.“But winning will make George 19-0. He is already really highly ranked and it’s about consolidating those rankings and getting a mandatory shot – whoever that’s against.”See also:Froch not keen on Groves fight – BoothGroves eyes title clash against StieglitzGroves weighs in ahead of O2 Arena 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 Follow West London Sport on TwitterFind us on Facebooklast_img read more

Helping the Environment, One Drop at a Time

first_imgThere is a lot of discussion about pervious paving and its contribution to the environment. Standard paving materials collect pollutants like oil, chemicals, and rubber tire particles from vehicles, pesticides, and dirt, only to have rain wash it off into our waterways, degrading our fresh water supply. Natural landscapes allow rain to percolate down through the soil, taking various pollutants with it, filtering and cleaning them as they flow down, typically arriving clean and clear by the time they reach the water table. We do need hard surfaces to walk, bike, and drive on, so what is the solution? Pervious paving to the rescue Available in many forms, pervious paving provides us with a surface both structurally sound and porous to water. Pervious concrete is similar to the standard product, but it’s made with smaller aggregate and no sand. The result is roughly the texture of a Rice Krispy treat, with open pockets that allow water to flow through the surface to the ground below. Usually placed over about 12 inches of gravel and a geotextile base, pervious concrete can absorb all but the most severe rain events, eliminating almost all water runoff wherever it is installed. Other pervious products include expanded plastic mesh filled with grass and porous paver stones installed over a gravel base.Do your part Reducing the amount of runoff from your project can provide additional points in almost every green-building program, it can help with building department approvals when you have to retain water on your lot, and it helps keep pollutants out of streams and rivers. The initial cost is higher than standard paving products, but like most things green, we get what we pay for. Once we stop looking at first costs and consider what our choices are doing to the environment as a whole, pervious products much more sense. And they’re fun to pee on, too.last_img read more

10 months agoJablonec star Michal Travnik watched by Newcastle, Fulham

first_imgJablonec star Michal Travnik watched by Newcastle, Fulhamby Chris Beattie10 months agoSend to a friendShare the loveCzech Republic midfielder Michal Travnik is attracting Premier League interest.The 24-year-old has been starring for Jablonec this season and has caught the eye with his performances, notably in the Europa League.The Daily Mail says Newcastle and Fulham are both looking to strengthen in January but they will face competition for Travnik.Bundesliga side Augsburg and CSKA Moscow have also been impressed this season.He has five caps for his country and is valued at around £4million by his club who are third in the league. TagsTransfersAbout the authorChris BeattieShare the loveHave your saylast_img

FS1’s Colin Cowherd On Controversial 2007 Sean Taylor Comments: “I Wish I Could Do That Over Again”

first_imgFS1's Colin Cowherd.With today’s launch of his new show Speak For Yourself, Colin Cowherd is poised to become one of the most important figures at Fox Sports 1, as it continues to shift to fit network president Jamie Horowitz’s infamous “embrace debate” strategy. The Washington Post‘s Rick Maese wrote a profile on Cowherd, where he admits his desire to be loved by viewers, and apologizes for one of his most notable on-air gaffes. After the death of former Miami Hurricanes and NFL superstar Sean Taylor, Cowherd blamed the victim, citing “23 years of bad judgment” as a reason for his death.Cowherd went on air and said, “Sometimes you’ve got stains, stuff so deep it never ever leaves. . . . And if you have bad judgment for 23 years of your life, even if you clean it up, your judgment doesn’t get great overnight.”He’s not proud of that today.“I just ad-libbed it. I think I was just too harsh,” he said. “That’s one of those, ‘Dammit, you know, I wish I could really take that back.’ . . . I wish I could do that over again, and I feel bad. But in my life, I can’t. It’s there. It’s somewhere archived. It’s just part of my biography, part of my archive. But I look at it now, I wish I could reel it back in. . . .“I probably should’ve scaled it back. I didn’t, and I paid a price. It made people very angry.”This was perhaps the worst of Cowherd’s many controversial stances, but it is far from his only one. Cowherd has long held a bizarre grudge against Washington Wizards point guard John Wall, after he did his signature dance before his first NBA game. Wall’s former college coach John Calipari has asked Cowherd to walk it back, but even after Wall won this year’s NBA Community Assist Award, Cowherd has not. Before leaving ESPN for FOX, Cowherd was suspended after asserting that Dominican baseball players are not well-educated.We don’t expect Cowherd to change much, especially as he expands to even more formats at FOX. That is a lot of time to fill, and like him or not, Cowherd is an expert at doing just that. [The Washington Post]MORE FROM COLLEGE SPUN:The 10 Most Aggressive Fan Bases In CFBIn Photos: Golfer Paige SpiranacESPN Makes Decision On Dick Vitalelast_img read more

VFS Global launches Cyprus visa centres in UK

first_imgTo offer greater accessibility and a seamless application process to UK residents and foreign nationals in the UK, VFS Global has launched four new application centres for the Embassy of the Republic of Cyprus.For higher quality and a more personalised service, applicants can opt for the premium service at these centres that offer assistance by a dedicated staff member during the submission process – including assistance in filling in the visa application and verification of documents and free access to photocopy, photo booth, SMS and courier services.Although UK visitors do not need a visa if they are staying less than 90 days, the new service will be of use to those who stay longer, such as those with holiday homes, those who spend more time in Cyprus visiting relatives, or those on long-term business trips. Cyprus is a hugely popular destination for UK visitors, the latest statistics show tourist arrivals from the UK increased by 25% in March 2018 compared to March 2017. The United Kingdom constituted the main source of tourism for Cyprus, with 35.5% arrivals. The newly launched services were inaugurated by Euripides Evriviades, High Commissioner, Embassy of the Republic of Cyprus in London. Commenting on the launch, Anirudh Pratap Singh, Chief Operating Officer, Europe, VFS Global, said, “Cyprus has always been a popular holiday destination for residents of the UK with nearly a million British nationals visiting this exotic location every year. We are confident that service solutions like the Premium Service at our centres will ensure a pleasant experience and efficiently cater to increasing demand.”VFS Global currently offers visa related assistance to the Cyprus mission in London with ongoing discussions to extend the scope of services to Consular and Passport services in the upcoming months.last_img read more

Mexico – Reported by Elite Traveler the Private J

first_imgMexico – Reported by Elite Traveler, the Private Jet Lifestyle MagazineSmooth Sailing The “Smooth Sailing” package includes a two-night stay in any of Garza Blanca’s suites or spacious Penthouses and a selection of fine foods as they cruise the clear waters of the Banderas Bay on the luxurious 70-foot Mondrian Yacht. Amenities include, a gourmet catering package of hors d’ouerves, snacks and dessert; children’s catering options and welcome baskets; premium “Mondrian Yacht Charter” t-shirts; unlimited beer, wine and soda; and towels and sunscreen.Delicioso Travelers can finally get the most out of their Mexican getaways: staying in luxurious five-star suites and tasting the finest of the local cuisine. Garza Blanca Preserve, Resort & Spa’s “Delicioso!” vacation package allows guests to taste the most succulent seafood and freshest ingredients at three of Puerto Vallarta’s top restaurants: Blanca Blue Restaurant & Lounge, Vitea Restaurant and Trio Restaurant. Visitors will enjoy three courses at each of these elegant restaurants, as well as enjoy three nights in the luxury suites and penthouses of Garza Blanca.www.garzablancaresort.comlast_img read more