Come on down, you’re the next contestant on The Price Is Right! If you’re lucky, you might even get host Drew Carey to crack a joke about a jam band.That’s what happened on a recent episode of the long-standing game show, when Carey used an actual string cheese to poke fun at the lengthy guitar solos that one might expect from The String Cheese Incident. The joke came during the pricing game “Pick a Pair,” where contestants have to choose items that have the same price.When the contestant Adam chose string cheese, Carey says “The String Cheese Incident… 45 minute guitar solo…” before revealing the price of the cheese. Watch it all go down below. While the original episode appeared in March, we didn’t catch the joke until the rerun today. Keep on Cheesin’, Drew!
The Beanstalk Music & Mountains Festival, hosted by the event’s namesake The Magic Beans, has announced that it will be returning once again to the majestic Rancho Del Rio Vail Valley after a successful first go-round at the site this past summer. Beanstalk organizers have confirmed the event will take place the weekend of June 22nd-25th, 2017, and feature a bevy of activities outside of what is sure to another top-notch lineup, including swimming, tubing, whitewater rafting, hot springs, and miles of hiking/biking trails. There is nothing quite like a Colorado music festival.The Magic of Beanstalk Festival: Supergroups & Collaborations In The Rocky MountainsLast year’s lineup saw The Magic Beans host acts such as Joe Russo’s Almost Dead, The New Mastersounds, Electron, and several solid super jams and collaborations, one of which being “The Magic Brownies,” which witnessed The Disco Biscuits’ Marc Brownstein led a supergroup which consisted of Tom Hamilton, Allen Aucoin and Beans members Scott Hachey and Casey Russel. Expect more of the same this year.Festival Director Ryan Noel discussed, “We couldn’t be more excited to return home at Rancho Del Rio. It’s what the fans wanted and what we wanted in 2016 but couldn’t make it work. We worked hand in hand with Eagle County to ensure we were able to return for 2017. No more shuttles! All the music will take place at Rancho which we’re thrilled about as well. Our ‘Early Bean’ tickets sold out in 48 hours so it’s looking like we’ll have consecutive sell-outs at Rancho as the capacity is super limited. We’ll be announcing artists in a few weeks in 2 waves as well.”And check out The Magic Beans perform two late-night shows in NYC on Dec. 30th and 31st post-Phish at American Beauty, with fellow up and comers Spafford (get tix for the 30th here, and 31st here).For additional festival information, click here.
Harvard Stem Cell Institute (HSCI) researchers at the Massachusetts General Hospital Center for Regenerative Medicine (MGH-CRM) have a developed a new type of human pluripotent stem cell that can be manipulated more readily than currently available stem cells. As described in the latest edition of Cell Stem Cell, these new cells could be used to create better cellular models of disease processes and eventually may permit repair of disease-associated gene mutations.“It has been fairly easy to manipulate stem cells from mice, but this has not been the case for traditional human stem cells,” explains Niels Geijsen, PhD, of the MGH-CRM, who led the study. “We had previously found that the growth factors in which mouse stem cells are derived define what those cells can do, and now we’ve applied those findings to human stem cells.”The first mammalian embryonic stem cells (ESCs) were derived from mice and have proven very useful for studying gene function and the impact of changes to individual genes. But techniques used in these studies to introduce a different version of a single gene or inactivate a particular gene were ineffective in human ESCs. In addition, human ESCs proliferate much more slowly than do cells derived from mice and grow in flat, two-dimensional colonies, while mouse ESCs form tight, three-dimensional colonies. It is been extremely difficult to propagate human ESCs from a single cell, which prevents the creation of genetically manipulated human embryonic stem cell lines.In previous work, Geijsen and his colleagues demonstrated that the growth factor conditions under which stem cells are maintained in culture play an important role in defining the cells’ functional properties. Since the growth factors appeared to make such a difference, the researchers tried to make a more useful human pluripotent cell using a new approach. They derived human induced pluripotent stem cells (iPSCs) – which are created by reprogramming adult cells and have many of the characteristics of human ECSs, including resistance to manipulation – in cultures containing the growth factor LIF, which is used in the creation of mouse ESCs.The resulting cells visibly resembled mouse ESCs and proved amenable to a standard gene manipulation technique that exchanges matching sequences of DNA, allowing the targeted deactivation or correction of a specific gene. The ability to manipulate these new cells depended on both the continued presence of LIF and expression of the five genes that are used in reprogramming adult cells into iPSCs. If any of those factors was removed, these hLR5- (for human LIF and five reprogramming factors) iPSCs reverted to standard iPSCs.“Genetic changes introduced into hLR5-iPSCs would be retained when they are converted back to iPSCs, which we then can use to generate cell lines for future research, drug development and someday stem-cell based gene-correction therapies,” says Geijsen. He is an assistant professor of Medicine at Harvard Medical School and a principal faculty member of the Harvard Stem Cell Institute.Co-authors of the Cell Stem Cell are lead author Christa Buecker, MGH-CRM and Harvard Stem Cell Institute (HSCI); Hsu-Hsin Chen, PhD, Laurence Dahern, and Konrad Hochedlinger, PhD, MGH-CRM and HSCI; Patricia Okwieka, MGH-CRM; Jose Polo, PhD, MGH Cancer Center; Lei Bu, PhD, MGH Cardiovascular Research Center; Tahsin Stefan Barakat and Joost Gribnau, PhD, University Medical Center, Rotterdam, The Netherlands; and Andrew Porter, PhD, Imperial College London, U.K. The study was supported by grants from the National Institutes of Health, the Dutch Science Organization, the Gottlieb Daimler and Karl Benz Foundation and the National Science Council of Taiwan.
Professor Jeffrey Quilter will be the next William and Muriel Seabury Howells Director of the Peabody Museum, beginning July 1.Quilter has been the Peabody Museum’s deputy director for curatorial affairs, curator for intermediate area archaeology, and senior lecturer in the Department of Anthropology. Prior to his arrival at the Peabody, Quilter spent 10 years as the director of pre-Columbian studies and curator of the pre-Columbian collection at Dumbarton Oaks in Washington, D.C.Quilter is best known for his team’s discovery of a lost language, written on a small piece of paper 400 years ago and excavated in 2008 at a colonial-period site in Peru.“I’m extremely honored and pleased,” said Quilter of his appointment. “This is a wonderful opportunity to lead a remarkable museum with committed staff in fulfilling its mission to serve Harvard University in its educational and research roles.”Read more information.
“The quality of a nit comb makes a big difference,” Guillebeau said. “The best are made out of steel. Inexpensive plastic combs are just not as good.”When parents use a nit comb, Pettis said it’s best to dip the comb in warm, soapy water after each sweep through the child’s hair.“The biggest take-home message to parents is to encourage schools not to spray pesticides,” she said. “Sprays expose children to unnecessary risks and aren’t effective for head lice management. And always use a nit comb. It’s an essential part of lice removal.” By Stephanie SchupskaUniversity ofGeorgiaEven Paul Guillebeau scratches his head when talking about head lice. The tiny creatures are his focus, especially when it comes to reducing students’ exposure to pesticides associated with the insect’s control.Guillebeau is an Extension entomologist with the University of Georgia College of Agricultural and Environmental Sciences. He and his colleague, Gretchen Pettis, are preparing for the onslaught of calls they’ll receive as soon as children across the state return to school.“Something like 15 million people get head lice each year,” said Guillebeau, who also serves as the college’s integrated pest management coordinator. “Additionally, there are numerous reports of head lice populations that are resistant to commonly available head lice shampoos.”It doesn’t matter what kind of socio-economic background or ethnicity a person has. Head lice aren’t selective when it comes to choosing a new host. But the negative connotation is still there.Guillebeau recalls one instance in particular. A mother called him because she said her children had head lice and the infestation was so bad “they were jumping off the cabinet.” He replied that head lice can’t jump, hop or fly. They can, however, crawl. This particular desperate mother had tried everything she could think of to get rid of the head lice. But they kept coming back. It turns out that her sister’s children had head lice, and her sister wouldn’t admit it so the children were being reinfested each time they played with their cousins.“The perception is always hard to overcome,” Pettis said. “Just because a child has head lice doesn’t mean that the child or the school is unclean.”The danger of a head lice outbreak isn’t the insect itself, because it doesn’t transmit diseases or cause illness. It’s the way schools and parents try to combat head lice.“The health risk is people doing foolish things with pesticides,” Guillebeau said.Pesticide sprays do little or nothing to control lice, a point Guillebeau and Pettis make in the head lice publications, “A Parent’s Guide to the ‘Nitty Gritty’ about Head Lice” and “A School’s Guide to the ‘Nitty Gritty’ about Head Lice.” The pamphlets are both available on the Web at http://entomology.ent.uga.edu/online_pubs.htm.The best way for school officials to combat an outbreak is to clean items like headphones and other objects that touch a student’s head. Students’ jackets, hats and scarves should also be stored separately. Guillebeau and Pettis also encourage early intervention by identifying children who have an infestation and notifying their parent or guardian.Head lice can’t form colonies in carpet or anywhere else in a home, Guillebeau said. They require a human host to spread an infestation and can “live off the body no more than a day or two.”Unlabeled treatments, such as kerosene and yard chemicals, applied to a child’s head can be dangerous. And medicated head lice shampoos won’t kill all the eggs, known as nits, Pettis said. The only way to get rid of head lice completely is with a combination of the shampoos and manual removal. To remove the nits, a parent or guardian must comb through each section of a child’s hair from the root all the way to the tip. (Stephanie Schupska is a news editor with the University of Georgia College of Agricultural and Environmental Sciences.)
Los Angeles Dodgers’ lineupCarl CrawfordPosition: LFAvg: .283 Position: CFAvg: .272HR: 12RBI: 52Steals: 4Surprisingly adept in center field filling in for Kemp last season, Ethier is team’s most versatile player in a crowded outfield.Yasiel PuigPosition: RFAvg: .319HR: 19RBI: 42Steals: 11Took the league by storm as a rookie in 2013, but 23-year-old Cuban faded late last season and needs to prove he’s not an off-field liability.Juan UribePosition: 3BAvg: .278HR: 12RBI: 50Steals: 5One of most important figures in the clubhouse, can 35-year-old be equally valuable on the field after surprisingly good 2013 season?Hanley RamirezPosition: SSAvg: .345HR: 20RBI: 57Steals: 10If he plays the way he did when healthy last season – Ramirez missed 76 games last year – he will be one of the favorites to win the National League MVP.Dee GordonPosition: 2BAvg: .234HR: 1RBI: 6Steals: 10Dodgers seem intent on finding a role for the speedy youngster. If not second base, Gordon could be a regular off a thin bench.Adrian GonzalezPosition: 1BAvg: .293HR: 22RBI: 100Steals: 1The most steady performer at the plate last season provides the team with stability in the lineup and in the locker room.A.J. EllisPosition: CAvg: .238HR: 10RBI: 52Steals: 0Made the most of his first full season in the major leagues in 2013, helping the Dodgers post the second-best team ERA in baseball.Los Angeles Dodgers’ rotationClayton KershawRecord: 16-9ERA: 1.83Innings: 236After signing a 7-year, $215 million contract in the offseason, Kershaw will attempt to lead the league in ERA for a fourth straight season.Zack GreinkeRecord: 15-4ERA: 2.63Salary: $21 millionAside from broken collar bone derailing his season for a couple months last year, Greinke pitched like an ace, could complete best 1-2 punch in baseball with Kershaw. Hyun-Jin RyuRecord: 14-8ERA: 3.00Innings: 192After proving he could handle major league competition by finishing 8th in the NL in ERA as a 26-year-old rookie, the South Korean has slimmed down for his second season.Dan HarenRecord: 10-14ERA: 4.67Innings: 169.2After winning 16 games in with the Angels in 2011, it has been downhill for Haren. He hopes a return to the West Coast will help him regain his form.Josh BeckettRecord: 0-5ERA: 5.19Innings: 43.1The 13-year veteran has won just two games in a Dodger uniform, has much to prove if he’s going to be productive fifth starter.Kenley JansenSaves: 28ERA: 1.88Innings: 76.2The Dodgers hope Jansen will be a fixture as their closer after the 26-year-old showed promise taking over the role in the middle of last season. Newsroom GuidelinesNews TipsContact UsReport an Error HR: 6RBI: 31Steals: 15Coming off best season since leaving Tampa Bay in 2010, four-time All-Star hopes last year was the beginning of a new chapter to his career.Andre Ethier