FILM SHOOT FOR SEAN PENNDIRECTED FLAG DAY SENDS MANITOBA TOWN TO THE

first_imgIn this file image, Sean Penn poses for a portrait in New York to promote a novel. (Taylor Jewell/Invision) Login/Register With: Facebook A number of older cars and trucks could be seen in La Salle on Rue Principale, which was also closed to traffic for the shoot..‘Flag Day’ is based on Jennifer Vogel’s non-fiction book about her father, ‘Flim-Flam Man’ and stars Penn, his children Dylan and Hopper Penn, Josh Brolin and Miles Teller.. Advertisement LEAVE A REPLY Cancel replyLog in to leave a comment center_img Advertisement Advertisement A street in a Winnipeg bedroom community got a retro makeover Wednesday for a film shoot of a feature directed by Sean Penn.According to a notice posted to a La Salle community Facebook group, the scenes for ‘Flag Day’ were set in the 80s, so parking had to be restricted to make sure all vehicles in view fit the time period. Twitterlast_img read more

Israeli Ban on Palestinian Entry May be Collective Punishment UN

Geneva – Israel’s cancellation of entry permits for Palestinians may amount to collective punishment, which is banned under international law, the United Nations’ top human rights official said on Friday. The Israeli military on Thursday revoked permits for 83,000 Palestinians to visit Israel during Ramadan, following a deadly attack in Tel Aviv, and said it would send hundreds more troops to the occupied West Bank after a Palestinian gun attack that killed four Israelis in Tel Aviv.On Friday, it said it was temporarily barring all Palestinians from entering Israel.“In accordance with government directives and the ongoing situation assessment, as of today crossing from the Gaza Strip and Judaea and Samaria (the West Bank) will be open to Palestinians only in medical and humanitarian cases,” a spokeswoman said. UN High Commissioner for Human Rights Zeid Ra’ad Al Hussein said he condemns the attack but is deeply concerned about the revoking of permits “which may amount to prohibited collective punishment and will only increase the sense of injustice and frustration felt by Palestinians,” spokeswoman Ravina Shamdasani told journalists at a press briefing in Geneva.With MAP read more

HRW Morocco Must Free Man Sentenced to 2 Years over Facebook

Rabat – Soufiane Al-Nguad may not have realized the consequences of his decision to, condemn the Royal Moroccan Navy shooting of a young migrant, Hayat Belkacem, in September. Through Facebook posts, he called on people to mourn Belkacem’s death and protest at a football game in Tetouan in northern Morocco.Human Rights Watch (HRW) has launched a call on the Moroccan government to free al-Nguad, the 29-year-old co-owner of a real estate agency sentenced on September 25 to two years in prison for “inciting people to participate in an unauthorized protest,” hate and violence on Facebook.Al-Nguad had also criticized the Moroccan government and kingdom, which authorities described as an “insult to the Moroccan flag,” a way of “spreading hatred,” and “calling for civil insurrection.” HRW wrote in a statement published on Friday, titled: “Morocco: Free Facebook Commentator,” that Morocco’s sentencing of al-Nguad was “a violation of his right to free speech.” The organization called on the country to “review his conviction given its abusive nature.”Sarah Leah Whitson, Middle East and North Africa director at Human Rights Watch, expressed condemnation over the court’s decision to convict al-Nguad, saying: “Soufian al-Nguad did nothing but express his anger and urge protests over the killing of an innocent woman…. The charges against him are illegitimate, and he should be freed immediately.”Read Also: Human Rights Watch’s 2019 Report on Morocco Criticizes IntoleranceAl-Nguad’s case is on appeal, and the trial will continue on February 11. In addition to the prison term, a Court of First Instance in Tetouan fined al-Nguad MAD 20,000.The court also charged the football fans who participated in the protest. Some of the fans were as young as 14, and the oldest arrested was only 23.The Royal Moroccan Navy opened fire on a migrant boat off the coast of M’diq and Fnideq in the Mediterranean on September 25, killing Hayat Belkacem, a 20-year-old native of Tetouan. The shooting made international headlines and sparked large condemnation. read more

Canopy Growth to acquire skincare company This Works for 738 million

SMITHS FALLS, Ont. — Canopy Growth Corp. has signed a deal to buy skin-care company This Works for $73.8 million in cash.The Ontario-based cannabis company says This Works will be part of its entry into the natural wellness industry and boost its international presence.Based in London, This Works offers a range of natural skin-care and sleep products.CBD, or cannabidiol, a compound derived from hemp and marijuana, is increasingly being used in a variety of products that tout health benefits.Canopy Growth says it will help This Works with the development of a new line of skin care and sleep solution products infused with CBD.This Works chief executive Anna Persaud is expected to remain at the helm of operations after the acquisition. The Canadian Press Companies in this story: (TSX:WEED)

YouTube updates hate speech guidelines to prohibit videos

SAN FRANCISCO — YouTube is updating its hate speech policies to prohibit videos with white supremacist and neo-Nazi content.The video streaming company says it has already made it more difficult to find such videos, but it’s now removing them outright. YouTube will also prohibit videos that deny certain proven events have taken place, such as the Holocaust.The changes come as YouTube, Facebook, Twitter and other online services face mounting concern that the platforms allow, and in some cases foster, extremism.YouTube’s new policies will take effect immediately.YouTube, which is owned by Google, says it’s removing thousands of channels that violate the new policies.The Associated Press

Global unemployment remains at historic high despite strong economic growth – UN

The number of people unemployed worldwide remained at an historical high of nearly 200 million in 2006 despite strong global economic growth, only modest gains were made in lifting some of the 1.37 billion working poor living on less than $2 per day out of poverty, and the pattern looks set to continue this year, according to a United Nations report released today. “To make long-term inroads into unemployment and working poverty, it is essential that periods of strong growth be better used to generate more decent and productive jobs,” the UN International Labour Organization (ILO) said in its annual Global Employment Trends. “Reducing unemployment and working poverty through creation of such jobs should be viewed as a precondition for sustained economic growth.” Even though more people are working globally than ever before, the number of unemployed remained at an all time high of 195.2 million last year, a global rate of 6.3 per cent, almost unchanged from 2005, with a forecast economic growth rate of 4.9 per cent for 2007 likely to ensure that unemployment remains at about the same level. “The persistence of joblessness at this rate is of concern, given that it will be difficult to sustain such strong economic growth indefinitely,” the report says, noting that that in order to maintain or reduce unemployment rates, the link between growth and jobs must be reinforced. Creation of decent and productive jobs – not just any jobs – is a prerequisite for reducing unemployment and slashing the number of families working but still living in poverty, which in turn is a precondition for future development and economic growth, it adds. “The strong economic growth of the last half decade has only had a slight impact on the reduction of the number of workers who live with their families in poverty and this was only true in a handful of countries,” ILO Director-General Juan Somavia said. For the last decade, economic growth has been reflected more in rising levels of productivity and less in growing employment, the report notes. While world productivity increased by 26 per cent the global number of those in employment rose by only 16.6 per cent. Unemployment hit young people aged 15 to 24 the hardest, with 86.3 million young people representing 44 per cent of the total unemployed in 2006. The employment gap between women and men persists. In 2006, only 48.9 per cent of women over age 15 were working compared to 49.6 per cent in 1996. The comparable male employment-to-population ratios were 75.7 in 1996 and 74.0 in 2006. In 2006, the share of the service sector in global employment progressed from 39.5 per cent to 40 per cent and for the first time overtook agriculture, which dropped from 39.7 per cent to 38.7 per cent. The industry sector represented 21.3 per cent of total employment. The largest decrease in unemployment occurred in the region of the Developed Economies and European Union, with a decline of 0.6 percentage points. East Asia’s rate was 3.6 per cent, remaining the lowest in the world, while the Middle East and North Africa remained the highest at 12.2 per cent. Sub-Saharan Africa stood at 9.8 per cent, the second highest and it also had the highest share in working poverty, with 8 out of 10 people living on less than $2 a day with their families. The total number of working poor on $1 a day declined between 2001 and 2006 except in Sub-Saharan Africa where it increased by another 14 million and in Latin America and the Middle East and North Africa where it stayed more or less unchanged. 25 January 2007The number of people unemployed worldwide remained at an historical high of nearly 200 million in 2006 despite strong global economic growth, only modest gains were made in lifting some of the 1.37 billion working poor living on less than $2 per day out of poverty, and the pattern looks set to continue this year, according to a United Nations report released today. read more

Earth Sciences students win photo contest

Photo by Meaghan Francis of a double rainbow over Noront Esker CampTwo Earth Sciences co-op students have won top prizes in a photo contest held by the Mining Industry Human Resources Council.Raja Yarra, a fourth-year student, won the Techno-Mine category for his picture of the St. Andrew Goldfields, Hislop Mine. Meaghan Francis, a third-year student, won in the Safety First! category for her picture of the Ontario Geological Survey at Pickle Lake. She also won in the Adventures in Mining category for her picture of a double rainbow over Noront Esker Camp.Yarra has completed two work placements at the Canadian Hydrographic Services and the St. Andrew Goldfields. He is also a varsity rower and treasurer of Brock’s Geology Club.Francis completed her first work placement last summer doing fieldwork for the Ontario Geological Survey. She also volunteered at a Prospectors and Developers Association of Canada conference earlier this year.• View all the winners in the Mining Industry Human Resources Council contestPhoto by Raja Yarra at the St. Andrew GoldfieldsPhoto by Meaghan Francis at Pickle Lake read more

Top UN official seeks to promote human rights in Central Asia

At the end of a three-day visit to Uzbekistan on Thursday, the Deputy High Commissioner for Human Rights, Bertrand Ramcharan, called for implementation of official commitments to “a strong and open civil society, respect for human rights and freedoms, a genuine multi-party system, free and fair elections, political pluralism, diversity of opinions and freedom to express them, independence of the media and the courts.”He noted that many problems prevailed and urged corrective measures. Numerous non-governmental organizations in Tashkent had made representations to him about a high number of political prisoners, the prevalence of capital punishment without adequate safeguards, the pervasive practice of torture and psychiatric abuse and the lack of independence of judges and prosecutors, he said.In Azerbaijan, Mr. Ramcharan discussed the importance of the rule of law and the role of judges in the protection of human rights with Justice Minister Fikret Mammedov, who briefed him on various areas of activities and publications intended to develop awareness of international human rights law among judges, lawyers, and prosecutors.The next stop of Mr. Ramcharan’s tour, a follow-up to UN Secretary-General Kofi Anan’s visit to the region in October 2002, is Turkmenistan. read more

New England Patriots Cut Tim Tebow

Tim Tebow has been released by the New England Patriots according to ESPN NFL Insider Adam Schefter.The quarterback, who signed with the Patriots in June, had a mediocre preseason. He completed 11 of 30 passes for 145 yards with two touchdowns and two interceptions throughout the preseason. Tebow wasn’t able to challenge Ryan Mallett for the second-string job behind Tom Brady.Tebow played his final preseason game Thursday night. Facing the New York Giants, he threw 6 of 11 passes for 91 yards, two touchdowns and one interception. The quarterback was also sacked four times.After Thursday’s game, the popular player was asked about chances of making the team, he said, “I’m not sure. I don’t make those decisions.”

Another combination of major iron ore resources – this time in West

first_imgFollowing the agreement between Rio Tinto and BHP Billiton in Western Australia’s Pilbara iron ore, the latter is in initial discussions with ArcelorMittal to potentially combine their respective iron ore mining and infrastructure interests in Liberia and Guinea. The iron ore interests of the two companies in Liberia and in Guinea are proximate and could be significantly more competitive if brought together in a combined operation. The parties say they “will be working together over the coming months to assess the merits of a partnership and will also work closely with the governments involved.” BHP-Billiton says “each firm’s execution capabilities and financial strength would provide an excellent platform on which to build an iron ore business in West Africa of world-class scale and scope and bring meaningful benefits to the region.”ArcelorMittal is the world’s leading steel company, with operations in more than 60 countries. It is the leader in all major global steel markets, including automotive, construction, household appliances and packaging, with leading R&D and technology, as well as sizeable captive supplies of raw materials and distribution networks. With an industrial presence in over 20 countries spanning four continents, the company covers all of the key steel markets, from emerging to mature. In 2008, ArcelorMittal had revenues of $124.9 billion and crude steel production of 103.3 Mt, representing approximately 10% of world steel output.ArcelorMittal is focusing on its mining activities, in accordance with its integrated business model. This is part of a strategy to actively develop the raw material base, thereby raising the level of iron ore self-sufficiency to 75%. Its iron ore assets straddle the Guinea-Liberia border. Mining there is restarting since the end of the civil war in Liberia, but is not currently active. First shipments are expected in 2011.Last year BHP-Billiton continued exploration activities and concept studies in Guinea at its Nimba deposit to determine the economic viability, sustainability impacts and management implications of a potential mine development in this area. In addition, it was carrying out exploration activities on various exploration leases it  holds in Liberia.last_img read more

Un séisme fait deux morts en Serbie

first_imgUn séisme fait deux morts en SerbieKraljevo, Serbie – Un séisme d’une magnitude de 5,6 s’est produit dans la nuit de mardi à mercredi en Serbie centrale. Deux morts sont à déplorer, tandis que des dizaines de blessés et d’importants dégâts sont évoqués dans la ville de Kraljevo.Comme l’a annoncé le ministre de l’Intérieur Ivica Dacic, un couple de quinquagénaires a perdu la vie à Grdica, près de Kraljevo, dans l’effondrement de sa maison.C’est à 1h56 (0h56 GMT), que s’est produite la secousse dont l’épicentre était, selon l’Institut sismologique serbe, situé à 10 kilomètres au nord de Kraljevo. Le tremblement de terre a été ressenti dans tout le pays, et la situation d’urgence a été proclamée sur le territoire de Kraljevo, qui a subi d’importants dégâts matériels, ainsi que dans les communes alentours. La ville, située à 150 kilomètres au sud-ouest de la capitale Belgrade, a été plongée dans l’obscurité et privée d’eau comme de lignes téléphoniques suite au séisme. En fin de matinée, environ 25% de la ville se trouvait toujours sans électricité.Alors que d’après les médias serbes, des dizaines de blessés ont été soignés par les services d’urgence, les équipes de sauvetage mobilisées sur le terrain n’ont pas découvert de victimes coincées sous les décombres, a indiqué le ministère.Le 3 novembre 2010 à 15:03 • Emmanuel Perrinlast_img read more

Le traquet motteux un mini oiseau capable de migration record

first_imgLe traquet motteux, un mini oiseau capable de migration recordLe traquet motteux est un oiseau de seulement 25 grammes capable de voyager depuis l’Arctique jusqu’à l’Afrique sub-saharienne. Selon une étude, il serait en mesure de parcourir chaque année 30.000 kilomètres.Le petit passereau insectivore connu sous le nom de traquet motteux se reproduit dans le nord du Canada et en Alaska à la saison chaude mais passe l’hiver dans des régions très éloignées. Ainsi, cet oiseau de 25 grammes seulement (l’équivalent de deux cuillères à soupe de sel !) est capable de migrer vers différentes régions d’Afrique pour y hiverner, ce qui lui fait parcourir chaque année pas moins de 30.000 kilomètres aller-retour.Rapporté à sa taille, ce cycle migratoire est l’un des plus longs jamais observé pour un quelconque oiseau dans le monde, estime l’étude qui révèle le record de ce mini-oiseau. Au cours de ces travaux publiés mardi dans la revue Biology Letters de l’Académie des sciences britannique, des biologistes canadiens et allemands ont utilisé des engins de géolocalisation miniaturisés de seulement 1,2 gramme. Ceux-ci leur ont permis de suivre en tout 46 traquets durant plusieurs mois et sur de longues distances. 30 d’entre eux ont été équipés en Alaska et 16 autres sur l’île de Baffin, située sur la côte arctique orientale du Canada, de l’autre côté du continent nord-américain.Seuls cinq des trente traquets d’Alaska équipés en 2009 sont revenus l’année suivante. Leur détecteur a alors révélé qu’ils avaient passé l’hiver en Afrique de l’est, aux confins du Soudan, de l’Ouganda et du Kenya. Durant l’automne, les oiseaux survolaient le nord de la Russie et le Kazakhstan avant de traverser le désert d’Arabie. Un périple d’environ 14.600 kilomètres qui leur a demandé trois mois. Au printemps suivant, ces oiseaux ont suivi la même route migratoire en sens inverse, en seulement 55 jours cette fois.Le seul oiseau terrestre à faire un tel voyage À lire aussiMaladie de Charcot : symptômes, causes, traitement, où en est on ?Les 16 traquets marqués dans l’est du Canada en 2010, eux, ont parcouru les 3.400 kilomètres séparant l’île de Baffin des îles britanniques en seulement quatre jours, soit une vitesse moyenne de 850 kilomètres par jour, souligne l’étude relayée par l’AFP. Ils ont alors bifurqué vers le sud, traversant l’Europe pour hiverner sur la côte de Mauritanie. Ils ont ensuite fait le voyage en sens inverse une fois le printemps revenu.Au vu de tels périples, “le traquet motteux est le seul oiseau terrestre connu qui relie physiquement deux écosystèmes radicalement différents entre le Vieux Monde et les régions arctiques du Nouveau Monde”, conclut Ryan Norris de l’université canadienne de Guelph (Ontario).Le 16 février 2012 à 09:37 • Maxime Lambertlast_img read more

Report – AS Roma want Ozan Kabak

first_imgItalian side AS Roma are reportedly prepared to pay the €7.5m release clause of teenage Galatasaray defender Ozan Kabak.The center-back who can also play as a defensive midfielder is currently negotiating a new deal that would almost treble the release clause.According to Football Italia, Giallorossi chief Monchi is the favourite to convince him into a move.However, there is also interest from Manchester United and Olympique Lyonnais.Chris Smalling open to a permanent AS Roma deal Andrew Smyth – September 6, 2019 Chris Smalling can “definitely see a longer-term future” for himself at AS Roma should things work out on his loan spell from Manchester United.Ozan Muhammed Kabak has been a subject of discussion among top clubs in Europe after putting up an impressive performance for Galatasaray in the Turkish Super Lig and UEFA Champions League.AS Roma are among the top Italian clubs looking to strengthen their squad during this transfer window as they prepare for the second half of the season.They also have a tough UEFA Champions League last 16 game against Portolast_img read more

Brewery Owners Worry New Bill Could Hinder Potential For New Business

first_imgDoug Hogue, the owner of Kenai River Brewery breaks down the 80/20 rule: “80% of everything that is manufactured has to go out into wholesale, and you can only sell 20% in your taproom.” Despite the growing popularity of craft breweries in the community Hogue says they face many challenges in the business: “To get into new facility you’re in the millions of dollars when you are looking getting this equipment. You have that and then going where they say you well you have to start distributing all of this beer, and if you are new you don’t have a market, you have nobody to help you move that beer. Even in 8 years it would be very difficult to recoup that capital investment.” According to Hogue, Kenai River who has been around for over 10 years isn’t hitting close to the proposed 80/20 mark: “We produce a good amount of beer and we distribute quite a bit, but we are still running 35-40% of our production through our taproom.” Story as aired: Audio PlayerJennifer-on-80-20-rule-for-breweries.mp3VmJennifer-on-80-20-rule-for-breweries.mp300:00RPd SB 76 currently before the Senate Labor and Commerce Committee. Hogue said he and other brewery owners feel that the 80/20 rule will hinder the ability for new breweries to be able to operate in the state. According to Hogue all of the production breweries in the state would not support the bill if the 80/20 rule remains written in. Senate Bill 76,“An Act relating to alcoholic beverages; relating to the regulation of manufacturers, wholesalers, retailers, and common carriers of alcoholic beverages.”  Written within the bill introduced by Sen. Micciche (R-K-Pen) seeks to institute an 80/20 rule for breweries in Alaska. Senate Bill 76 is a third installment to Senate Bill 99 that was introduced in April 2015 by Senator Peter Micciche (R-K-Pan) but was not addressed during the 29th Legislature. Facebook0TwitterEmailPrintFriendly分享Local production brewery owners worry that a portion of a bill being introduced by the State Legislature would eliminate the potential for any new breweries in Alaska. Doug Hogue will be a guest on KSRM-920AM on Monday, March 5, at 9 A.M. for sound off to further discuss Senate Bill 76.last_img read more

Senate authorizes funding for FAA air carrier services to Diomede

first_imgFor decades, Diomede has scrambled to fund reliable air carrier service. On Tuesday, the small island community got one step closer to a long-term solution for passenger travel and mail delivery. The US Senate voted to reauthorize the Federal Aviation Administration with a new amendment that would guarantee federal funding for the island of Diomede.Download AudioThe native village of Little Diomede sits on the border of Russia and the United States. (U.S. Coast Guard Photo by Petty Officer Richard Brahm)Diomede is smack dab in the middle of the Bering Strait, closer to Russia than it is to the continental US. The remote community relies on air carrier services for everything from milk to medication. That’s why an amendment to include Diomede in the FAA’s Reauthorization Bill is a big boost for the community.“This is a huge, fundamentally important life, health and safety issue for them,” explained John Bioff. Bioff is an attorney for Kawerak, the Native non-profit corporation for the Bering Strait Region.Up until now, Bioff said he’s struggled to secure steady funding for air carrier services to the island.“To have to go back to the state every year, not knowing whether or not this year we’re going to be able to keep the Diomede funding in the state budget, is horrible,” Bioff said.In 1978 the FAA established the Essential Air Service, or EAS, program. It subsidizes air carrier service to small communities throughout the country, including sixty in Alaska. Diomede isn’t one of them. It’s had to rely on a mix of state and federal funding, which Kawerak reapplies for each year.In 2015, Diomede received about $190,000 in federal funding and relied on state grants to double that.Senator Dan Sullivan learned about Diomede’s dire situation a few months back. He’s on the Senate Commerce, Science, and Transportation Committee.“I recognize how difficult any kind of economic issues are without essential air service, particularly in some of most remote locations, so we got to work,” said Sullivan.The FAA Reauthorization Bill sailed through the U.S. Senate 95-3. The House is working on its own FAA bill, which does not include a special provision for Diomede, is bogged down over a controversial section that would privatize air traffic control.last_img read more

Infosys Plunges on Promoters Share Sale News Where is a Billion Dollar

first_imgInfosys Ltd saw its shares fall 4% on Monday on news that its co-founders are set to sell shares worth almost $1.1billion. ReutersThe sale, said to involve four of its co-founders and their families, are to offer 32.6 million shares in the IT outsourcing firm for a fixed price of ₹1,988 ($32) each, a 4% discount to Friday’s close.Narayana Murthy, Nandan Nilekani, S.D.Shibulal and K.Dinesh, have been named as those offloading the shares.Deutsche Bank is the sole book runner for the issue and the books were covered just after launch, according to IFR, a Thomson Reuters publication.As of September 2014, the founders and their families hold about 16% of shares outstanding. Nandan NelikaniReutersInfosys launched a 1:1 bonus share issue earlier this month. The shares being offloaded could be the the pre-bonus equity stake.In June, Vishal Sikka was chosen as the tech major’s CEO, breaking a trend of the founding members heading the organisation for more than three decades. The last few years had seen the company flounder, while its counterparts did roaring business.Founder-Members Investment ProfileNarayana Murthy’s Catamaran Ventures has a strategic partnership with global retail giant, Amazon, for its India business. Murthy is also known to invest in various realty projects across the country. His other interests include FMCG and education. Reuters FileShibulal’s family office, Innovations Investment Management (IIM), manages investments in hospitality, property management, project management, investment portfolio management, plantations, farms and education. The company also owns an 800-apartment block in Seattle, USA.Nandan Nilekani and his wife Rohini together are worth ₹7,700 crore, with 80% of it tied to their combined ownership of 2.75% in Infosys Ltd. They are well known philantrophists. ReutersK.Dinesh, who resigned from the board in 2011, has been devoting his time to social work in the areas of health care, education and governance.At the time of reporting, information on what the promoters seek to do with the funds is unavailable.last_img read more

The origins of handedness in life

first_img © 2014 Phys.org Finding supports model on cause of DNA’s right-handed double helix Handedness is a complicated business. To simply say life is left-handed doesn’t even begin to capture the blooming hierarchy of binary refinements it continues to evolve. Over the years there have been numerous imaginative theories for how life’s amino acids, nucleic acids, and sugars came to favor one orientation over another. Everything from circularly polarized UV light, magnetism of the Earth, oriented clays or quartzes, to the weak nuclear force itself has been considered, but none has yet to securely emerge into realm of plausibility. A recent paper by Dreiling and Gay in Physical Review Letters has now thrown a life jacket to the weak force making it a theoretically viable possibility. To fully vet the author’s conception a little work needs to be done. Effort well spent we might say, because to understand where and when the handedness of life’s molecules originated is to know the origin of life. Citation: The origins of handedness in life (2014, October 1) retrieved 18 August 2019 from https://phys.org/news/2014-10-handedness-life.html Journal information: Physical Review Letters Explore further The capital “L” forms of aminos acids are the chiral orientations mostly preferred in our proteins. They are said to be left-handed when referenced to the optical activity of an L-glyceraldehyde molecule from which they could in theory be derived. However nine of our nineteen L-amino acids are actually dextrorotatory with a lowercase d (rotate polarized light to the right), when measured at the standard optical wavelength of 589 nm. Similarly the D orientation of glucose, the dextrose of life, rotates light to the right, while D-fructose actually rotates it to the left. The handedness of the DNA helix is more straightforward to assign than values for optical rotation of constituent molecules with multiple chiral centers. The A-DNA helix which life mostly employs, threads to the right when viewed from either direction as sure as a nut threads in either direction on the machinist’s screw. While the debate continues on the exact order in which the many key molecules of life first appeared, amino acids have been the center of attention. One possible explanation for their chirality is that circularly polarized (CP) light preferentially destroyed one amino acid enantiomer over the other, potentially giving it a head start. This idea gained some support when CP radiation in the infrared band was discovered in the Orion Nebula. The main problem with this idea is that CP also destroys much of the “correct” amino acid form as well. Moreover, the magnitude and orientation preference for the effect depends on the frequency of the light. The desireable bias—L selection for the narrow UV light band—would be swamped by competing broadband effects with the result that any long term amplification would grow asymptotically small.Experimentatlly, the CP theory of handedness is not completely dead, only weak. The best result to date has been the creation of 20% optically pure camphor in the lab. Unfortunately this was only obtained after 99% of the original stock was destroyed. If the D form amino acids are life’s cancer, than CP light hardly seems to be the most effective chemotherapy. The weak nuclear force, one the other hand, may be a bit more interesting for the origins of chirality. It is one of the four fundamental forces of nature and governs a particular kind of radioactive decay known as β-decay. The weak force has a peculiar handedness, called parity violation, which preferentially produces left-handed electrons during β-decay. For electrons with a left-handed “helicity”, the directions its of spin and motion are opposite to each other.center_img More information: Chirally Sensitive Electron-Induced Molecular Breakup and the Vester-Ulbricht Hypothesis J. M. Dreiling and T. J. Gay, Phys. Rev. Lett. 113, 118103 – Published 12 September 2014. journals.aps.org/prl/abstract/ … ysRevLett.113.118103 Chirality of life. Credit: wikipedia Richard Feynman Beta decay, and the events occuring around it, are perhaps much better described with Feyman diagrams than with words. For many of us, simply explaining why a mirror “appears” to flip left and right but not top and bottom requires more than just imagining circling around it to appear inside it. Determining the far more complex mechanisms that underlie life’s handedness will likely remain a significant challenge for some time. In 1967 Vester and Ulbricht suggested that spin-polarized electrons could have directly generated the kind of CP light described above (as so-called bremsstrahlung radiation) to directly enrich the enantiomeric precursors of life. While notable, that mechanism leaves us right back where we were with the CP light shortcomings mentioned above. In this void, other researchers have suggested the polarized electrons themselves, either from radioactive decay or as cosmic rays hailing at the appropriate energy, might be the emissaries of chirality. Against this tableau of uncertaintly there is an interesting theoretical implication of parity violation. That is that both L-amino acids and D-sugars are slightly more stable then their opposites. Unfortunately, the energy differences we are talking about here are only about 10–17 kT. In a racemic mixture of L and D form amino acids, that energy corresponds to an L excess of only one per every 6×10^17 molecules.Finding evidence that direct beta interactions can transmit chirality to organic molecules has been difficult. What distinguishes the results just reported by Dreiling and Gay is that the uncertainty regarding a photonic or electronic mechanism can be reduced by mimicking beta radiation with longitudinally polarized electrons produced in the laboratory at a precisely controllable energy. The researchers used a brominated form of camphor in which an electron could cause release of the bromine in a process known as dissociative electron attachment (DEA). The key to their success was to use incident electrons with low velocity and energy to maximize the “chirality sampling” interactions.In a nutshell, they found that left-handed bromocamphor reacted better with right-handed electrons at modest energies, and better with left-handed electrons at the lowest energies. The effect was small, but enough to take the Vester-Ulbricht Hypothesis to the next level. This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only.last_img read more

Synthetic Genomics unveils digitaltobiological converter using digital DNA to print biologics

first_img What if you could launch a machine aboard a rocket to Mars and then transmit information describing a life form, which the machine then “prints?” That is what the team at SG envisions. Or more practically, they envision sending the digitized DNA of a deadly virus from a remote outbreak zone to a research lab that uses the information to develop a vaccine. Once created, the same converter machine could then be used to print the material for creating the vaccine locally.The device is actually a hodgepodge of smaller devices that contribute to the whole. One of the main pieces is the BioXP 3200—a synthetic DNA printer that is already marketed around the world to researchers who use it to easily create synthetic DNA samples. The rest of the pieces receive information and process it and deal with the printed materials—the head of the project at SG, for example, can send a message from his office to the machine and then walk over and collect a virus it has created. This is not a means for creating life, the researchers note, because viruses are not considered forms of life. Instead, it is described as a “digital to biological converter for on-demand production of biologics.”Researchers at SG have used the device to remotely synthesize viruses and claim they are on the cusp of doing the same with a so-called minimal cell, a major step toward remotely printing material for creating living organisms. But first, they have to fix what they describe as an unacceptable rate of mutations.In their paper and announcement, the company highlights the positive uses for the machine, but notably avoid mentioning the negative—the ability to use the machine to produce a virus at a given location that could be released as a biological weapon. Citation: Synthetic Genomics unveils digital-to-biological converter using digital DNA to print biologics (2017, August 7) retrieved 18 August 2019 from https://phys.org/news/2017-08-synthetic-genomics-unveils-digital-to-biological-digital.html Credit: CC0 Public Domain Using machine vision for 3-D printing © 2017 Phys.org More information: Kent S Boles et al. Digital-to-biological converter for on-demand production of biologics, Nature Biotechnology (2017). DOI: 10.1038/nbt.3859center_img Journal information: Nature Biotechnology This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only. A team of researchers at Synthetic Genomics (SG) has unveiled a machine they call a digital-to-biological converter—it sends digitized information describing DNA, RNA or a protein to a device that prints out synthesized versions of the original material. The team has published a paper describing their creation in the journal Nature Biotechnology. Explore furtherlast_img read more

Carnival Spirit departs Sydney for dry dock in Singapore

first_imgCarnival Spirit departs Sydney for dry dock in SingaporeCarnival Spirit sails out of Sydney Heads today, embarking on a 19 day cruise to Singapore, ahead of her dry dock later this month.Carnival is investing into upgrades that will provide holidaymakers a range of new family friendly entertainment features offering new spaces for kids activities onboard. This includes a new arts and crafts area named SoulPlay, and a brand new entertainment area for teenagers, Warehouse Arcade.Cruise lovers hoping to be some of the very first to enjoy these upgrades can sail on Carnival Spirit’s 19 day Singapore to Sydney cruise, departing on 6 June 2018.This 19 day cruise will sail to some of Carnival’s rare ports of call such as Phuket, Bali (Benoa), Darwin and Airlie Beach, before arriving back to Sydney.For the remainder of 2018, Carnival Spirit will sail from Sydney to stunning destinations such as New Caledonia, Vanuatu and Moreton Island.For more information or to book, visit carnival.com.au or your travel agent or call 13 31 94.About Carnival Cruise Line:Carnival Cruise Line is the largest cruise line in the world with almost five million guests travelling every year. The cruise line has two ships deployed in Australia, including Carnival Spirit – currently the largest and newest cruise ship home ported year round in Australia. Sister ship Carnival Legend will return to Australia in October 2018 following her Northern Hemisphere summer season cruising Alaska. Carnival Splendor will join the Australian Carnival fleet in December 2019 and become the newest and largest ship home ported year-round in Australia. With 45 activities to enjoy each day, Carnival’s ships offer fun-loving families and couples fun, memorable holidays at great value.Source = Carnival Cruise Linelast_img read more